Research Project

ARDS - Long-term Outcomes of Specific Ventilator Strategies

Project Description: 
This project is part of a SCCOR grant which is looking at Molecular Approaches to Ventilator Associated Lung Injury. It fits nicely in the SCCOR grant because it focuses on long-term outcomes of patients with ALI. Acute Lung Injury (ALI) is relatively common and associated with significant short term mortality. The incidence of ALI is estimated to be 75 per 100,000 persons and historically has had 40% hospital mortality. Evidence from the ALI Network suggests that 28-day mortality can be reduced from 40% to 31% with the use of Conventional Ventilation Lung Protection. To improve the care of patients with ALI, we need to better understand the barriers to compliance with CVLP, the long-term mortality and other outcomes associated with ALI, and the therapies that may be associated with those outcomes. In addition, future efforts could identify genetic determinants in patients receiving CVLP that may be associated with reduced mortality.

Specific Aims:

1. a. To evaluate the use of CVLP as a care strategy in a cohort of patients with ALI
   b. To identify patient, provider and organizational barriers for use of CVLP.
   
   
2. To evaluate association between CVLP ventilation and other aspects of care with long-term mortality in patients with ALI
   
   
3. A secondary aim is to explore the association between CVLP and other aspects of care with a broad group of patient outcomes specifically addressing --